Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR
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چکیده
منابع مشابه
Chronic stress alters dendritic morphology in rat medial prefrontal cortex.
Chronic stress produces deficits in cognition accompanied by alterations in neural chemistry and morphology. Medial prefrontal cortex is a target for glucocorticoids involved in the stress response. We have previously demonstrated that 3 weeks of daily corticosterone injections result in dendritic reorganization in pyramidal neurons in layer II-III of medial prefrontal cortex. To determine if s...
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چکیده ندارد.
15 صفحه اولmTOR Signaling and Dendritic Cell Biology
Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells (APCs) specialized to capture, process, and present antigens to T lymphocytes [1]. DCs develop from bone marrow (BM)-derived precursor populations, including monocyte and dendritic cell progenitors (MDPs) and common DC progenitors (CDPs) that subsequently give rise to plasmacytoid DCs (pDCs) and conventional DCs (c...
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Therapeutic irradiation of the brain is a common treatment modality for brain tumors, but can lead to impairment of cognitive function. Dendritic spines are sites of excitatory synaptic transmission and changes in spine structure and number are thought to represent a morphological correlate of altered brain functions associated with hippocampal dependent learning and memory. To gain some insigh...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2014
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2014.124